Cultural traits or social norms? Both responsibilism and norms linked to accepting covid-19 vaccine

We studied the factors that influence attitudes toward the COVID-19 vaccine by testing 1872 people across 29 provinces in China. We investigated an individual trait (responsibilism) and two situational factors (a descriptive norm and an injunctive norm). Responsibilism is a version of collectivism that emphasizes tight social ties and responsibilities in close relationships. Responsibilism and perceptions of strong social norms predicted acceptance of the COVID-19 vaccine. The data also revealed an interplay between responsibilism and social norms. People high in responsibilism accepted the vaccine regardless of social norms. But people low in responsibilism were wary of the vaccine, unless they perceived strong injunctive norms. These findings contribute to the research on psychological factors behind vaccine hesitancy. The findings could help provide a roadmap for public health efforts to encourage vaccines. (PsycInfo Database Record (c) 2023 APA, all rights reserved)

TMPRSS2 Inhibitor Discovery Facilitated through an In Silico and Biochemical Screening Platform.

The COVID-19 pandemic has highlighted the need for new antiviral approaches because many of the currently approved drugs have proven ineffective against mitigating SARS-CoV-2 infections. The host transmembrane serine protease TMPRSS2 is a promising antiviral target because it plays a role in priming the spike protein before viral entry occurs for the most virulent variants. Further, TMPRSS2 has no established physiological role, thereby increasing its attractiveness as a target for antiviral agents. Here, we utilize virtual screening to curate large libraries into a focused collection of potential inhibitors. Optimization of a recombinant expression and purification protocol for the TMPRSS2 peptidase domain facilitates subsequent biochemical screening and characterization of selected compounds from the curated collection in a kinetic assay. In doing so, we identify new noncovalent TMPRSS2 inhibitors that block SARS-CoV-2 infectivity in a cellular model. One such inhibitor, debrisoquine, has high ligand efficiency, and an initial structure-activity relationship study demonstrates that debrisoquine is a tractable hit compound for TMPRSS2.

Primary care provider perspectives on virtual and in-person depression management during the COVID-19 pandemic.

INTRODUCTION: During the COVID-19 pandemic, primary care providers (PCPs), nurses, and integrated mental health specialists continued to collaboratively manage depression among patients using both in-person and virtual (i.e., hybrid) modalities. Few studies have characterized how hybrid services are currently delivered within interdisciplinary primary care teams. This study aimed to understand frontline PCPs' perspectives on providing hybrid virtual and in-person depression care during the pandemic. METHOD: From September to November 2020, 12 semistructured individual interviews focused on depression management were conducted with PCPs in two Veterans Health Administration (VA) clinics in Los Angeles, which resumed in-person services while balancing rising COVID-19 cases. Interviews were audio-recorded, transcribed, and coded for depression management patterns. Themes were derived using a team-based constant comparative analytic approach. RESULTS: The pandemic and subsequent expanded use of virtual care necessitated clinic adaptations to depression assessments and procedures. PCPs perceived increased depression and anxiety among patients with existing psychiatric conditions, attributed to social distancing and isolation restrictions. They expressed acceptance of virtual care modalities for patients' depression management. PCPs did not perceive a delay in mental health care delivery in the shift to virtual care but noted the possibility of patients being lost to follow-up. CONCLUSIONS: During the pandemic, there has been heightened PCP concern for patients' emotional well-being and adaptations of clinic processes to meet needs for depression care. While PCPs were optimistic about new virtual care options for depression management, virtual care transfers remained poorly defined and the extent to which patient care experiences and health outcomes have been disrupted remains unknown. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

Cardiopulmonary testing in long COVID-19 versus non-COVID-19 patients with undifferentiated Dyspnea on exertion.

BACKGROUND: Dyspnea and fatigue are characteristics of long SARS-CoV-2 (COVID)-19. Cardiopulmonary exercise testing (CPET) can be used to better evaluate such patients. RESEARCH QUESTION: How significantly and by what mechanisms is exercise capacity impaired in patients with long COVID who are coming to a specialized clinic for evaluation? STUDY DESIGN AND METHODS: We performed a cohort study using the Mayo Clinic exercise testing database. Subjects included consecutive long COVID patients without prior history of heart or lung disease sent from the Post-COVID Care Clinic for CPET. They were compared to a historical group of non-COVID patients with undifferentiated dyspnea also without known cardiac or pulmonary disease. Statistical comparisons were performed by t-test or Pearson's chi2 test controlling for age, sex, and beta blocker use where appropriate. RESULTS: We found 77 patients with long COVID and 766 control patients. Long COVID patients were younger (47 ± 15 vs 50 ± 10 years, P < .01) and more likely female (70% vs 58%, P < .01). The most prominent difference on CPETs was lower percent predicted peak V̇O2 (73 ± 18 vs 85 ± 23%, p < .0001). Autonomic abnormalities (resting tachycardia, CNS changes, low systolic blood pressure) were seen during CPET more commonly in long COVID patients (34 vs 23%, P < .04), while mild pulmonary abnormalities (mild desaturation, limited breathing reserve, elevated V̇E/V̇CO2) during CPET were similar (19% in both groups) with only 1 long COVID patient showing severe impairment. INTERPRETATION: We identified severe exercise limitation among long COVID patients. Young women may be at higher risk for these complications. Though mild pulmonary and autonomic impairment were common in long COVID patients, marked limitations were uncommon. We hope our observations help to untangle the physiologic abnormalities responsible for the symptomatology of long COVID.

Cardiac Tamponade as a Complication of Microscopic Polyangiitis: A Case Associated With a COVID-19 mRNA Vaccine.

Widespread uptake of the coronavirus disease 2019 (COVID-19) vaccinations has become the world's championed defense against the global pandemic. Four vaccines have been either approved or authorized for emergency use by the FDA, and at this time, over 13 billion doses of these vaccines have been administered around the world. Unfortunately, uncommon and sometimes unforeseen side effects such as small-vessel vasculitis have been reported. In this case report, we present a 74-year-old woman with a history of hypertension, type 2 diabetes mellitus, and hypothyroidism who developed microscopic polyangiitis (MPA) following the second dose of the Pfizer-BioNTech mRNA vaccine for COVID-19. The diagnosis of MPA was confirmed by a kidney biopsy. The autoimmune condition progressed to pericardial effusion and eventual cardiac tamponade, which is occasionally seen in the disease. In this patient's case, we suspect there to be a temporal association between mRNA COVID-19 vaccination and the development of MPA. Direct causation has not been determined.

SARS-CoV-2 infections in patients enrolled on the Children's Oncology Group standard-risk B-cell acute lymphoblastic leukemia trial, AALL1731

Hematologic malignancy is a risk factor for severe coronavirus disease 2019 (COVID-19) in adults;however, data specific to children with leukemia are limited. High-quality infectious adverse event data from the ongoing Children's Oncology Group (COG) standard-risk B acute lymphoblastic leukemia/lymphoma (ALL/LLy) trial, AALL1731, were analyzed to provide a disease-specific estimate of SARS-CoV-2 infection outcomes in pediatric ALL. Of 253 patients with reported infections, the majority (77.1%) were asymptomatic or mildly symptomatic (CTCAE grade 1/2) and there was a single COVID-19-related death. These data suggest SARS-CoV-2 infection does not confer substantial morbidity among young patients with B-lymphoblastic leukemia/lymphoma (B-ALL/LLy).Copyright © 2023 The Authors. eJHaem published by British Society for Haematology and John Wiley & Sons Ltd.

Frequency of Parkinson disease following COVID-19 infection: A two-year retrospective cohort study.

INTRODUCTION: COVID-19 infection is known to cause various neurological symptoms, and potentially increases the risk of developing subsequent neurodegenerative conditions including parkinsonism. To our knowledge, no study to date has used a large data set in the United States to ascertain the risk of developing incident Parkinson disease in patients with history of COVID-19 infection compared to the risk amongst those without prior COVID-19 infection. METHODS: We utilized data from TriNetX electronic health records network which includes 73 healthcare organizations and over 107 million patients. We compared adult patients with and without COVID-19 infection, with health records from January 1, 2020 through July 26, 2022, to determine the relative risk of developing Parkinson disease stratified by 3-month intervals. We used propensity score matching to control for patients' age, sex, and smoking history. RESULTS: We collected data on 27,614,510 patients meeting our study criteria: 2,036,930 patients with a positive COVID-19 infection (COVID-19) and 25,577,580 without a positive COVID-19 infection (non-COVID-19). After propensity score matching, age, sex, and smoking history differences became non-significant, with 2,036,930 patients in each cohort. After propensity score matching, we found significantly increased odds of new onset Parkinson disease in the COVID-19 cohort at three, six, nine, and twelve months from the index event, with peak odds ratio at six months. After twelve months there is no significant difference between the COVID-19 group and non-COVID-19 group. CONCLUSIONS: There may be a transiently increased risk of developing Parkinson disease in the first year following COVID-19 infection.

Pandemic Depression: COVID-19 and the Mental Health of the Self-Employed: ET&P

We investigate the effect of the COVID-19 pandemic on self-employed people's mental health. Using representative longitudinal survey data from Germany, we reveal differential effects by gender: whereas self-employed women experienced a substantial deterioration in their mental health, self-employed men displayed no significant changes up to early 2021. Financial losses are important in explaining these differences. In addition, we find larger mental health responses among self-employed women who were directly affected by government-imposed restrictions and bore an increased childcare burden due to school and daycare closures. We also find that self-employed individuals who are more resilient coped better with the crisis.

Pandemic Depression: COVID-19 and the Mental Health of the Self-Employed

We investigate the effect of the COVID-19 pandemic on self-employed people's mental health. Using representative longitudinal survey data from Germany, we reveal differential effects by gender: whereas self-employed women experienced a substantial deterioration in their mental health, self-employed men displayed no significant changes up to early 2021. Financial losses are important in explaining these differences. In addition, we find larger mental health responses among self-employed women who were directly affected by government-imposed restrictions and bore an increased childcare burden due to school and daycare closures. We also find that self-employed individuals who are more resilient coped better with the crisis.

Passion amid the pandemic: Applying a person-centered approach to examine cross-domain multi-passion profiles during a crisis

We examine whether having cross-domain passion (i.e., harmonious and obsessive passion for work and for non-work activities) during the COVID-19 pandemic can help individuals fare better amid the crisis. Drawing from work-family boundary framework, we develop a provisional theory of cross-domain multi-passion, and in two studies, we use latent profile analysis to uncover five passion profiles - Dispassionate at Work and Play;Dispassionate at Work, Ambidextrous at Play;Harmonious at Work, Ambidextrous at Play;Harmonious at Work and Play;and Moderately Harmonious at Work and Play. In Study 1, we inductively explore these profiles and their relationships with life satisfaction. In Study 2, we replicate the number and content of these profiles, and test whether segmentation-integration preferences and work and non-work constraints predict the probability of individuals belonging to a certain profile. Overall, these profiles reveal how individuals can co-host multiple forms of passion simultaneously, and how doing so relate to their life satisfaction during the pandemic. (PsycInfo Database Record (c) 2023 APA, all rights reserved)

Supporting Professionals in Critical Care Medicine: Burnout, Resiliency, and System-Level Change.

Burnout is occurring in epidemic proportions among intensive care unit physicians and other health-care professionals-accelerated by pandemic-driven stress. The impact of burnout is far-reaching, threatening the health of individual workers, the safety and quality of care our patients receive, and eroding the infrastructure of health care in general. Drivers of burnout include excessive quantity of work (nights, weekends, and acuity surges); excessive menial tasks; incivility, poor communication, and challenges to team success; and frequent moral distress and end-of-life issues. This article provides system-based practice and individual strategies to address these drivers and improve the well-being of our team and our patients.

Complex of Ceftriaxone with Mg(II): Synthesis, Structure, Spectral and Antibacterial Properties

Аннотация. Получен и охарактеризован магниевый комплекс цефтриаксона методами атомно-эмиссионного и элементного анализов, ТГА, ИК- и КР-спектроскопии, РФА и расчетов теории функционала плотности. Цефтриаксон координируется к иону магния через кислород триазинового цикла в шестом положении, азот аминогруппы тиазольного цикла и атомы кислорода карбоксильной и лактамной групп. Динатриевая соль цефтриаксона и комплекс магния были исследованы на антибактериальную активность в отношении Staphylococcus aureus, Escherichia coli и Pseudomonas aeruginosa.Alternate abstract:Magnesium complex of ceftriaxone was obtained and characterized by atomic-emission and elemental analysis, TGA, FTIR and Raman spectroscopy, X-ray diffraction and density functional theory calculations. Ceftriaxone was coordinated to the magnesium ion by the oxygen of the triazine cycle in the 6th position, the nitrogen of the amine group of the thiazole ring, and oxygen atoms of the lactam carbonyl and carboxylate groups. The disodium salt of ceftriaxone and magnesium complex were screened for antibacterial activity against Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa.

Effectiveness of Remote Cardiac Rehabilitation: A Meta-Analysis

Background Cardiac rehabilitation (CR) is a Class 1 indication for patients following acute coronary syndrome, coronary intervention and in patients with chronic, stable heart failure. However, rates of participation remain abysmal. Following the COVID-19 pandemic, interest in remote cardiac rehabilitation (R-CR) has increased. Efficacy of R-CR versus the current standard of care remains unclear. Methods A systematic review of the available literature was performed according to the PRISMA 2020 checklist. Of the identified studies, further screening was done to isolate randomized controlled trials (RCT) that measured objective markers of physical fitness such as peak oxygen consumption during exercise (VO2 max) and distance traveled during 6 minute walk test (6MWT). Results 20 RCTs were identified that compared R-CR versus either standard CR or usual care that did not include a component of CR. There is no difference in the change in exercise capacity achieved based on whether a patient underwent R-CR versus standard CR. There was a significant difference in the change in exercise capacity achieved in patients who underwent R-CR versus usual care. R-CR is associated with a significant change in VO2 max but not distance walked on 6MWT. Conclusion R-CR is not inferior to standard CR in improving VO2 max and distance walked on 6MWT. R-CR may be superior to usual care that does not include an element of CR. This is potentially beneficial as increased adoption of R-CR may improve participation in CR as a whole. [Formula presented]Copyright © 2023 American College of Cardiology Foundation

Genetic Liability to Cannabis Use Disorder and COVID-19 Hospitalization.

BACKGROUND: Vulnerability to COVID-19 hospitalization has been linked to behavioral risk factors, including combustible psychoactive substance use (e.g., tobacco smoking). Paralleling the COVID-19 pandemic crisis have been increasingly permissive laws for recreational cannabis use. Cannabis use disorder (CUD) is a psychiatric disorder that is heritable and genetically correlated with respiratory disease, independent of tobacco smoking. We examined the genetic relationship between CUD and COVID-19 hospitalization. METHODS: We estimated the genetic correlation between CUD (case: n = 14,080; control: n = 343,726) and COVID-19 hospitalization (case: n = 9373; control: n = 1,197,256) using summary statistics from genome-wide association studies. Using independent genome-wide association studies conducted before the pandemic, we controlled for several covariates (i.e., tobacco use phenotypes, problematic alcohol use, body mass index, fasting glucose, forced expiratory volume, education attainment, risk taking, attention-deficit/hyperactivity disorder, Townsend deprivation index, chronic obstructive pulmonary disease, hypertension, and type 2 diabetes) using genomic structural equation modeling. Genetic causality between CUD and COVID-19 hospitalization was estimated using latent causal variable models. RESULTS: Genetic vulnerability to COVID-19 was correlated with genetic liability to CUD (r G  = 0.423 [SE = 0.0965], p = 1.33 × 10-6); this association remained when accounting for genetic liability to related risk factors and covariates (b = 0.381-0.539, p = .012-.049). Latent causal variable analysis revealed causal effect estimates that were not statistically significant. CONCLUSIONS: Problematic cannabis use and vulnerability to serious COVID-19 complications share genetic underpinnings that are unique from common correlates. While CUD may plausibly contribute to severe COVID-19 presentations, causal inference models yielded no evidence of putative causation. Curbing excessive cannabis use may mitigate the impact of COVID-19.

Fear during pandemic promoted holistic cognitive style: The moderating role of uncertainty.

The present study explored the link between fear and holistic cognitive style and the moderating role of uncertainty. We examined these effects in a real-life situation: the long-term, global COVID-19 pandemic, which provided a natural context of fear and uncertainty. The current study comprises three studies recruiting N = 1,310 participants. Study 1 compared the link between fear and holistic style in the United States (a relatively uncertain situation presented by the COVID-19 pandemic) and China (a pandemic situation with relative certainty) in the early days of the pandemic. Study 2 examined the moderation effect of uncertainty in the relationship between fear and holistic style by manipulating participants into a fearful (vs. control) condition. Study 3 employed a longitudinal design to demonstrate the effect of fear-related emotions on holistic style change over a 3-month period. Across three studies, the moderation effect of uncertainty in the relationship between fear-related emotions and holistic style during the COVID-19 pandemic was consistently observed. In sum, this study provided an ecological and explanatory mechanism for understanding the impact of individuals' fear on holistic cognitive style. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

Critical Care Staffing in Pandemics and Disasters: A Consensus Report From a Subcommittee of the Task Force for Mass Critical Care - Systems Strategies to Sustain the Health Care Workforce.

BACKGROUND: The COVID-19 pandemic has led to unprecedented mental health disturbances, burnout, and moral distress among health care workers, affecting their ability to care for themselves and their patients. RESEARCH QUESTION: In health care workers, what are key systemic factors and interventions impacting mental health and burnout? STUDY DESIGN AND METHODS: The Workforce Sustainment subcommittee of the Task Force for Mass Critical Care (TFMCC) utilized a consensus development process, incorporating evidence from literature review with expert opinion through a modified Delphi approach to determine factors affecting mental health, burnout, and moral distress in health care workers, to propose necessary actions to help prevent these issues and enhance workforce resilience, sustainment, and retention. RESULTS: Consolidation of evidence gathered from literature review and expert opinion resulted in 197 total statements that were synthesized into 14 major suggestions. These suggestions were organized into three categories: (1) mental health and well-being for staff in medical settings; (2) system-level support and leadership; and (3) research priorities and gaps. Suggestions include both general and specific occupational interventions to support health care worker basic physical needs, lower psychological distress, reduce moral distress and burnout, and foster mental health and resilience. INTERPRETATION: The Workforce Sustainment subcommittee of the TFMCC offers evidence-informed operational strategies to assist health care workers and hospitals plan, prevent, and treat the factors affecting health care worker mental health, burnout, and moral distress to improve resilience and retention following the COVID-19 pandemic.

Collective Resilience and Coping Mechanisms Among International Faculty Members Amid Snap Lockdowns During the Delta and Omicron Variant Outbreaks in East China.

This study explores international faculty members' resilience and the active challenges to establishing coping mechanisms while facing a mental health crisis provoked by the Delta and Omicron lockdowns in China. Grounded in a qualitative approach, this study used a transcendental phenomenological methodology to examine 16 international faculty members affiliated with higher education institutions in Shanghai, Hangzhou, and Nanjing. The findings showed that participants had various mental health issues amid snap lockdowns and persistent nucleic acid application tests. They perceived the most influential sources of coping mechanisms to be (a) social and emotional support; (b) prosocial behavior; and (c) engagement with the public and social services alongside the domestic faculty members. This study emphasizes the significance of collective resilience and prosocial behaviors, calling on future scholars to pay more attention to the host group's cultural values and community resilience as coping mechanisms during the public health crisis provoked by the pandemic.

Face mask and medical waste generation in the City of Baguio, Philippines: its current management and GHG footprint.

The daily use of facemask to prevent virus transmission increases the negative effect on the environment because of improper waste disposal. Due to the absence of baseline data, the impact of facemask and medical waste generation, as well as the community's management practice, should be studied to avoid further environmental degradation. In this study, we surveyed 384 respondents and conducted computational analysis to provide an overview of the household's facemask usage and ecological footprint in combating Covid-19. Results showed that most respondents (48.7%) use two facemasks per day. Thus, an estimated 417,834 facemasks are disposed daily, generating 3,585 kg/day of additional waste. The average medical waste of Covid-infected individuals is 3.29 kg per day per capita. This yields 22,438 kg. of CO2 eq., which could contribute to the global warming potential; however, there is also a potential recovery of 61.572 gigajoules of energy for power generation. Most respondents are aware of proper facemask waste management practices, but some lacks application regarding responsible waste disposal. Despite the contribution of facemask to the overall solid waste generation, the city's current management remains a challenge since disposable facemasks are potentially mixed with other types of waste from its storage, collection, and disposal. Supplementary Information: The online version contains supplementary material available at 10.1007/s10163-023-01601-2.

Face mask and medical waste generation in the City of Baguio, Philippines: its current management and GHG footprint

The daily use of facemask to prevent virus transmission increases the negative effect on the environment because of improper waste disposal. Due to the absence of baseline data, the impact of facemask and medical waste generation, as well as the community's management practice, should be studied to avoid further environmental degradation. In this study, we surveyed 384 respondents and conducted computational analysis to provide an overview of the household's facemask usage and ecological footprint in combating Covid-19. Results showed that most respondents (48.7%) use two facemasks per day. Thus, an estimated 417,834 facemasks are disposed daily, generating 3,585 kg/day of additional waste. The average medical waste of Covid-infected individuals is 3.29 kg per day per capita. This yields 22,438 kg. of CO2 eq., which could contribute to the global warming potential;however, there is also a potential recovery of 61.572 gigajoules of energy for power generation. Most respondents are aware of proper facemask waste management practices, but some lacks application regarding responsible waste disposal. Despite the contribution of facemask to the overall solid waste generation, the city's current management remains a challenge since disposable facemasks are potentially mixed with other types of waste from its storage, collection, and disposal. Supplementary Information The online version contains supplementary material available at 10.1007/s10163-023-01601-2.